The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Carpendale & Lewis's (C&L's) theory falls in with an existing set of theories that children's understanding of mind is collaboratively constructed in linguistically mediated social interaction. This social constructivist view needs to be clear about the complementary contributions of the child and of the social environment. I distinguish between the child's individual linguistic ability and the dyad's social communication, proposing that each makes a contribution to theory-of-mind development, differently balanced in different individuals.

Remodel[l]ing Reality is an inquiry into Wittgenstein's notion of übersichtliche Darstellung and the phenomenon of installation in visual art. In a sense, both provide a perspicuous overview of a particular part of our complex world, but the nature of the overview differs. Although both generate knowledge, philosophy via the übersichtliche Darstellung gives us a view of how things stand for us, while the installation shows an unexpected, exiting point of view. The obvious we tend to forget and the ambiguity of (...) reality are related to each other in a dynamic way. It is in this reflexive dynamics that we constantly remodel our reality. Tools we use are our creative abilities and our powers of imagination. In our choices and solutions we show which aspects of reality we find important and how we communicate these values. The outcome of this investigation is a new perspective on the art of installation and a new insight in Wittgenstein's notion of übersichtliche Darstellung. Because of this combination, the book is itself an artwork: an InstallationPackage. The book is distributed by Ideabooks Amsterdam, Isbn 978 90 804240 3 6. Remodel[l]ing Reality is included in Special Collections, Allard Pierson Museum Amsterdam. (shrink)

Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (Aiapy, Aiy, Asy and Avy) were recently shown to result from insertions that cause ubiquitous expression of chimeric transcripts encoding a wild‐type agouti protein(1,2). (...) Three insertions were identified as intracisternal A‐particles, which helps explain the variable coat colors and parental imprinting effects associated with some dominat agouti alleles. (shrink)

Insight, by F. H. Parker.--Why be uncritical about the life-world? By H. B. Veatch.--Homage to Saint Anselm, by R. Jordan.--Art and philosophy, by J. M. Anderson.--The phenomenon of world, by R. R. Ehman.--The life-world and its historical horizon, by C. O. Schrag.--The Lebenswelt as ground and as Leib in Husserl: somatology, psychology, sociology, by E. Paci.--Life-world and structures, by C. A. van Peursen.--The miser, by E. W. Straus.--Monetary value and personal value, by G. Schrader.--Individualisms, by W. L. McBride.--Sartre the individualist, (...) by W. Desan.--The nature of social man, by M. Natanson.--The problem of the will and philosophical discourse, by P. Ricoeur.--Structuralism and humanism, by M. Dufrenne.--The illusion of monolinear time, by N. Lawrence.--Can grammar be thought? By J. M. Edie.--The existentialist critique of objectivity, by S. J. Todes and H. L. Dreyfus.--Bibliography (p. 391-400). (shrink)

I describe and articulate the merits of an elegant supplemental exercise that I call “Philosophy in the Wild” (PW), which has students initiating a philosophical dialogue outside the classroom and critically reflecting on the results. The PW exercise is especially effective if used to reinforce philosophic texts which have dialogue as their form or as their subject matter (or both)—for instance, Plato’s Apology and Meno. However, the PW exercise is also an engaging, effective way simply to introduce students to the (...) practice and the value of philosophy. (shrink)

As the world population is growing and government directives tell us to consume more fatty acids, the demand for fish is increasing. Due to declines in wild fish populations, we have come to rely more and more on aquaculture. Despite rapid expansion of aquaculture, this sector is still in a relatively early developmental stage. This means that this sector can still be steered in a favorable direction, which requires discussion about sustainability. If we want to avoid similar problems to the (...) ones we have experienced with livestock farming, we need to generate knowledge of the biology, profitability, environmental aspects, consumer awareness, and product appreciation of particular fish species. However, the discussion about a sustainable aquaculture also raises the question how we should treat fish. This moral question is regularly addressed as a problem of applied ethics with a focus on tailoring ethical principles to practical questions. In this article we do not deny the importance of the practical accounts, but we start from the fundamental question whether and why fish matter in our moral deliberations, i.e., from the discussion on moral status. We elaborate the distinction between moral considerability and moral significance in order to show both the importance and the limitations of the discussion about moral status for practical problems in aquaculture. We illustrate these points with a case-study about the farming of a specific fish species, the African catfish. (shrink)

The central role played by Darwin's analogy between selection under domestication and that under nature has been adequately appreciated, but I have indicated how important the domesticated organisms also were to other elements of Darwin's theory of evolution-his recognition of “the constant principle of change,” for instance, of the imperfection of adaptation, and of the extent of variation in nature. The further development of his theory and its presentation to the public likewise hinged on frequent reference to domesticates.We have seen (...) that Darwin's reliance on the analogy between domesticated varieties and wild species was a bold and original step, in light of contemporary views on the nature of domesticates. However, as Darwin undoubtedly foresaw, his reliance on the analogy created difficulties as well as solving problems, and these began with his Malthusian codiscoverer of the principle of natural selection, Alfred Russel Wallace. Wallace's paper “On the Tendency of Varieties to Depart Indefinitely from the Original Type,” presented to the Linnean Scoiety along with the first public unveiling of Darwin's theory, states: We see, then, that no inferences as to varieties in a state of nature can be deduced from the observation of those occurring among domestic animals. The two are so much opposed to each other in every circumstance of their existence, that what applies to the one is almost sure not to apply to the other. Domestic animals are abnormal, irregular, artificial; they are subject to varieties which never occur and never can occur in a state of nature.62Much has been made of the similarity of views of Darwin and Wallace, but this quotation surely reveals how utterly different their views were on what to Darwin was an important matter. Several critics of the Origin saw Darwin's reliance on the domesticates as his Achilles heel. As Young has pointed out, Samuel Wilberforce included the following passage in his attack on the Origin: Nor must we pass over unnoticed the transference of the argument from the domesticated to the untamed animals. Assuming that man as the selector can do much in a limited time, Mr. Darwin argues that Nature, a more powerful, a more continuous power, working over vastly extended ranges of time, can do more. But why should Nature, so uniform and persistent in all her operations, tend in this instance to change? Why should she become a selector of varieties?63Another critic, Fleeming Jenkin, found the analogy a weakness in Darwin's theory because of the limited extent of variation in any one direction in domestic animals and plants.64 We have already seen that Darwin had confided a similar view to his notebook thirty years earlier, but changed his mind as a result of his profound study of domesticates. De Beer's reference to “an English country gentleman's knowledge of domestic plants and animals and their breeding”65 fails totally to recognize the originality and depth of Darwin's knowledge of domesticates.Why did Darwin, against the currents of his time, rely so heavily on mankind's experience with domesticated organisms to shape his theory about species in nature? On reason is that only with domesticates was an approach that came close to experimental verification possible. Darwin fully realized the inadequacies of the experiment, as is emphasized by his repeated contrasting of selection under nature and selection by man. Yet the extensive experience and data of plant and animal breeders offered the only reliable base against which Darwin could continually challenge his views. As he wrote in the introduction to Variation, with domestication, “man ... may be said to have been trying an experiment on a gigantic scale.”66 Given Darwin's high opinion of the quantitative work of Malthus and Quetelet (as emphasized by Schweber),67 and his unremitting efforts to secure data by which to test his theories, it was inevitable that he should attach high significance to domesticated varieties. John Tyndall, in his Belfast address of 1874, said: “The strength of the doctrine of Evolution consists, not in experimental demonstration (for the subject is hardly accessible to this mode of proof), but in its general harmony with scientific thought.”68 Darwin would have agreed with the latter thought, but I think he would have challenged the preceding one on the grounds that long experience with domesticated varieties did provide an element of experimental demonstration. It gave him confidence in his theory, and he used his vast knowledge of artificial selection boldly and creatively. (shrink)

It has been argued that if non-human animals had rights we should be obliged to defend them against predators. I contend that this either does not follow, follows in the abstract but not in practice, or is not absurd. We should defend non-humans against large or unusual dangers, when we can, but should not claim so much authority as to regulate all the relationships of wild things. Some non-human animals are members of our society, and the rhetoric of 'the land (...) as a community' is an attempt, paralleling that of humanism, to create the moral ideal of Earth's Household. But wild animals should be considered as Nozick's 'independents' and have correspondingly fewer claims on our assistance than members of our society. They still have some claims, often strong ones. (shrink)

In this short note, we discuss several aspectsof dimensions and the related constructof factors. We concentrate on those aspectsthat are relevant to articles in this specialissue, especially those dealing with the analysisof the wild animal cases discussed inBerman and Hafner's 1993 ICAIL article. We reviewthe basic ideas about dimensions,as used in HYPO, and point out differences withfactors, as used in subsequent systemslike CATO. Our goal is to correct certainmisconceptions that have arisen over the years.

Innovation is a key component of most definitions of culture and intelligence. Additionally, innovations may affect a species' ecology and evolution. Nonetheless, conceptual and empirical work on innovation has only recently begun. In particular, largely because the existing operational definition (first occurrence in a population) requires long-term studies of populations, there has been no systematic study of innovation in wild animals. To facilitate such study, we have produced a new definition of innovation: Innovation is the process that generates in an (...) individual a novel learned behavior that is not simply a consequence of social learning or environmental induction. Using this definition, we propose a new operational approach for distinguishing innovations in the field. The operational criteria employ information from the following sources: (1) the behavior's geographic and local prevalence and individual frequency; (2) properties of the behavior, such as the social role of the behavior, the context in which the behavior is exhibited, and its similarity to other behaviors; (3) changes in the occurrence of the behavior over time; and (4) knowledge of spontaneous or experimentally induced behavior in captivity. These criteria do not require long-term studies at a single site, but information from multiple populations of a species will generally be needed. These criteria are systematized into a dichotomous key that can be used to assess whether a behavior observed in the field is likely to be an innovation. (shrink)

In 1913, the British suffragette Emily Wilding Davison was killed when she ran onto the race course at Epsom Downs during the running of the Derby. Davison's goals are unclear, but she was immediately hailed as a martyr to the women's cause by her comrades in the Women's Social and Political Union. Others denounced her as a suicidal fanatic. This article evaluates Davison's death by examining the WSPU's emphasis on self-sacrifice, the actions of other women who risked their lives (...) for the right to vote, and Davison's political writings and activities. Combined, these features of the militant suffrage movement support the WSPU's identification of Davison as a martyr. They also raise questions about the ideological integrity of the concept of secular martyrdom. (shrink)

Johnson (English, U. of Kansas) explores the present crisis in education, especially in the US, by surveying broad changes in recent curricular and pedagogical theory and practice. These changes entail a shift from teaching to instructing from students learning what the teacher knows to learning.

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

The first of my preliminary arguments which Mr. Wild feels to be erroneous is that in which possibility is held to involve both being and non-being. In defending this thesis I return to the original problem to which it attempted a preliminary solution. The pervasiveness of contingency and change in human experience was first asserted, together with the demand that metaphysics explain, as best it might, all such data; with this much I understand Mr. Wild to agree in the opening (...) paragraph of his critique. Further it was affirmed that through awareness of contingency and change, the understanding comes to possess the concepts of being and nonbeing, and can see that both contingency and change must involve these two concepts. With Mr. Wild I agree that "There is a gulf between being and non-being." To bridge this gulf, then, to mediate these terms, is the very function of possibility. It was this gulf that demanded an intermediate conception, and the characteristics attributed to this mediator were, at the outset, simply those which its function seemed to require. My whole preliminary account of the possible, then, was constructed strictly with this function in mind. Upon careful re-consideration of the matter, I find myself still holding that the bridging of this chasm between the simple non-being of an entity and the simple being of that same entity requires intermediation of precisely the sort that I first offered. How else can we proceed, either in thought or existence, from the non-being of X to the being of X, except by means of that which exceeds but has its basis in the former, and tends toward but falls short of the latter? (shrink)

To believe in fairies is not to believe in rare Lepidoptera or the like, within a basically materialistic context. It is to take folk?stories seriously as accounts of the ?dreamworld?, the realm of conscious experience of which our ?waking world? is only a province, to acknowledge and make real to ourselves the presence of spirits that enter our consciousness as moods of love or alienation, wild joy or anger. In W. B. Yeats's philosophy fairies are the moods and characters of (...) human life, conceived not as alterations in a material being, but as the spiritual rulers of an idealistically conceived world. Yeats follows folklore in making them ambivalent: either the sweet undying voices of nature or the disillusioned destroyers of humane life. His prophecies of a New Age were of a world ruled unknowingly by fairies, spirits invoked by music, poetry, and love, that do not necessarily take much care of ordinary human life. The ?Fairy Faith? described by Yeats and Evans?Wentz is a variety of idealism, and by no means absurd. (shrink)

Now that we have looked at the characteristics of mystical experience, we are ready to discuss the assumption made in this paper that mystical experience can be translated into an understanding of “integration” or the drive for meaning which Fingarette pursues in a much more analytic fashion. Reviewing the conversion process as an “integration” process we have seen that for the sick-souled, beset with the meaninglessness or melancholy which paralyzes his will, his own awareness of wrong in his situation prevents (...) him from opening up to larger views of reality. But, as James has described, at the same time as the subject is attending so strongly to his own sense of worthlessness, “all the while the forces of mere organic ripening within him are going on towards their own prefigured result, and his conscious strainings are letting loose subconscious allies behind the scenes, which in their way work toward rearrangements.” Yet the “rearrangements” can only come about by obeying the command of Chaung-Tse: “Cease striving.” The result is self-transformation in “reconciling, unifying states.” There is achieved “a supersensuous meaning to the ordinary outward data of consciousness; facts already objectively before us fall into a new expressiveness and make a new connection with our active life.”However, James cautions us to realize that the same incursions of the subconscious which produce such “reconciling, unifying states” can also produce pathological states, “a diabolical mysticism, a sort of religious mysticism turned upside down.” In such a state the “meanings” of events become dreadful and the ruling emotion is pessimism. To this possibility James applied the pragmatic test, “By their fruits...,” and concluded that the mystical experience which brings optimism to the individual is a genuine experience and one which brings truth. In our context then, we would say that real “integration” brings the subject away from the “melancholy” and meaninglessness he felt into the “genuinely insightful resolution” of which Fingarette speaks.Conversion, then, is a process in James's analysis of religious experience analogous to the process of integration and meaning-discovery while mysticism is analogous to the state in which integration or meaning-discovery is achieved. Conversion is climaxed by self-surrender; mysticism is characterized by new determination, self-transformation: two ways of describing an indivisible event. Furthermore, the four characteristics James applies to mysticism are indeed characteristic of the experience of integration.Two other points should be added here which are much in line with James's treatment of experience. In the first place, one of the basic principles of radical empiricism is that not only objects but relations between objects are the subject of experience. Such an experience of relationships, of wholeness, is exactly what characterizes integration. At the same time, the five senses are suspended, and the “insight” is experienced with such a strong immediacy that it is almost sensed. James refers to this quality of mystical states: The records show that even though the five senses be in abeyance in them, they are absolutely sensational in their epistemological quality, if I may be pardoned the barbarous expression, - that is, they are face to face presentations of what seems immediately to exist.I am not saying that every integration is a mystical experience. Rather I have been saying that James's discussion of religious experiences such as healthy-minded, sick-souled, melancholy, conversion, and mysticism provide analogues for better understanding the phenomenological processes and characteristics of the drive for meaning and integration which Fingarette analyzes. In fact, the very notion of religion itself for James bears not just an analogous resemblance but perhaps an identification with integration. For in his personal letters James had defined religious experience as “Any moment of life that brings the reality of spiritual things more ‘home’ to one.” And in Varieties James defines religion as “a man's total reaction upon life....; his attitude towards what he felt to be the primal truth.”If we look upon this outlook of James toward religion as an “exaggeration” of the reality of integration, we can follow James to what he perceives as the importance of religion upon an individual's life. The man of religious feeling possesses “the excitement of a higher kind of emotion,” an “enthusiastic temper of espousal in regions where morality strictly so called can at best but bow its head and acquiesce.” So we are brought again to the area of creativity in which an individual has experienced the widening of the area of his immediate experience and is “re-born” in the karmic pattern, a valid pattern for both James and Fingarette. As Fingarette describes it, the “converted” individual “creates” values which the dead reality he had previously faced did not possess. The result of the achieved integration is explained by James when referring to religious experience as “an excitement of the cheerful, expansive, ‘dynamogenic’ order which, like any tonic, freshens our vital powers.” This emotion “overcomes temperamental melancholy [meaninglessness] and imparts endurances to the subject, or a zest, or a meaning, or an enchantment and glory to the common objects of life.”We might sum up this discussion not by a criticism of the shortcomings of James's treatment of the religious life, such as his apparent insensitivity to the part played by institutions in the religious experience itself, but rather by underscoring the richness of the phenomenological analysis James has undertaken. James Edie acknowledges that James's studies of religious experience itself rather than of religion. ... are not only more sound phenomenologically than some of the studies which have, under the influence of Husserl, up to now explicitly invoked the phenomenological method, but they are also the first to establish any solid basis for a true phenomenology of religious experience.And John Wild has pointed out the parallel between James's concept of melancholy and Heidegger's concept of anxiety as the genesis of the process of becoming: beginning with the prospect of death and nothingness, the individual gropes toward new birth.As we have seen, then, James's analysis of the varieties of religious experience leads to a fruitful discussion of the psychological processes involved in melancholy and meaninglessness, rearrangement and integration. In all such experiences, a sense of inner unity is reached to which the following words of Fingarette would apply by analogy: The soul-racking death which leads to blissful “rebirth” is the death of the subjectively experienced, anxiety-generated “self” perception; it is the emergence into the freedom of introspective “self-forgetfulness” of the psychically unified self. (shrink)

Standard virtue ethics approach to environmental issues do not go far enough because they often lack significant attachment to local environments. Place provides the necessary link that enlarges the arena of moral action by joining human well-being to a place -based goal of wildness or biotic harmony. Place defines a niche for human activity as part of nature. Virtuous action, then, is understood as deliberation from a position of being in and of the natural world; respect and gratitude are examples (...) of this type of deliberation. (shrink)

A recent report by Tyner et al.1 suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild‐type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair‐mediated protection against cancer and ageing. So (...) what are we to make of the new data with regard to overall understanding of the mechanisms of ageing? BioEssays 24:577–579, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Leo Strauss's controversial writings have long exercised a profound subterranean cultural influence. Now their impact is emerging into broad daylight, where they have been met with a flurry of poorly informed, often wildly speculative, and sometimes rather paranoid pronouncements. This book, written as a corrective, is the first accurate, non-polemical, comprehensive guide to Strauss's mature political philosophy and its intellectual influence. Thomas L. Pangle opens a pathway into Strauss's major works with one question: How does Strauss's philosophic thinking contribute to (...) our democracy's civic renewal and to our culture's deepening, critical self-understanding? This book includes a synoptic critical survey of writings from scholars who have extended Strauss's influence into the more practical, sub-philosophic fields of social and political science and commentary. Pangle shows how these analysts have in effect imported Straussian impulses into a "new" kind of political and social science. (shrink)

Sustainability and welfare are concepts that are often mentioned in the context of fishing and fish farming. What these concepts imply in practice, how they are defined and made operational is less clear. This paper focuses on the role of fish buyers as a key actor in the supply chain between the fisher or fish farmer and the consumer. Using semi-structured interviews, we explore and analyze whether and how the interviewed fish buyers define and implement moral values related to animal (...) welfare and sustainability. The eight fish buyers who were interviewed suggest that moral values are used in their work, but also result in a number of value conflicts (moral and non-moral). The focus on sustainability and animal welfare appear to be driven by external and market factors. Sustainability mainly reflects fishing methods and quotas and fish welfare is seen as part of sustainability. Fish welfare seems more important for farmed than for wild fish as the buyers feel a responsibility regarding these kept animals. Further, the decision whether a product is sustainable is mainly based on labels. Fish buyers argue that labels are useful as a business-to-business tool. Nonetheless, based on the interviews, we argue that the relevance of these labels for addressing the ethical dilemmas of buyers is limited. Labels often are a rather procedural solution that deals with the genuine dilemmas only to a limited extent. We conclude that in order to move forward, the sector needs to further reflect and elaborate on its core values. (shrink)

When people speak of ‘the law of the jungle’, they usually mean unions restrained and ruthless competition, with everyone out solely for his own advantage. But the phrase was coined by Rudyard Kipling, in The Second Jungle Book, and he meant something very different. His law of the jungle is a law that wolves in a pack are supposed to obey. His poem says that ‘the strength of the Pack is the Wolf, and the strength of the Wolf is the (...) Pack’, and it states the basic principles of social co-operation. Its provisions are a judicious mixture of individualism and collectivism, prescribing graduated and qualified rights for fathers of families, mothers with cubs, and young wolves, which constitute an elementary system of welfare services. Of course, Kipling meant his poem to give moral instruction to human children, but he probably thought it was at least roughly correct as a description of the social behaviour of wolves and other wild animals. Was he right, or is the natural world the scene of unrestrained competition, of an individualistic struggle for existence? (shrink)

In this book, Stephen R.L. Clark defends the primary faith of humankind, that there is a real world which is more than a shadow of our desires and fancies, and which can be discovered through right reason. Focusing on the way in which we can "turn aside" to the Truth from the normal delusions of self-concern, Clark offers a properly worked, Platonic metaphysics as the key to identifying that reality. This book is the final volume of Limits and Renewals, a (...) trilogy based on the author's Stanton lectures, delivered at Cambridge between 1986 and 1989, and his Wilde lectures, delivered at Oxford in 1990. (shrink)

Thus the extrinsic argument against ag biotech. In considering whether it is a good argument, I believe we should simply assume that is true. Substantially risky technologies, perhaps by definition, should not be developed. Seeing no reason to contest, therefore, I will focus on.

This article advances what it calls the ‘Impossibility Result’: it is impossible to claim that the reduction of exploitation leads to the improvement of efficiency. The Impossibility Result is the inevitable result of the proposed conceptual difference between ‘injustice’ and ‘exploitation’. Injustice occurs when one member of a society deviates from the norms and the legal rules concerning how one should treat other members of that society. Exploitation occurs when one member of a society takes advantage of entities such wild (...) animals, cattle, a field of vegetables, or other people that lie outside the boundary of that society. In many cases of exploitation, the exploited may derive some benefit, as in the case when enslavement is better than death. In other cases of exploitation, the exploited may derive zero benefit, called here ‘harm’, as in the case when a deer is hunted. (shrink)

DNA sequence variation is abundant in wild populations. While molecular biologists use genetically homogeneous strains of model organisms to avoid this variation, evolutionary biologists embrace genetic variation as the material of evolution since heritable differences in fitness drive evolutionary change. Yet, the relationship between the phenotypic variation affecting fitness and the genotypic variation producing it is complex. Genetic buffering mechanisms modify this relationship by concealing the effects of genetic and environmental variation on phenotype. Genetic buffering allows the build-up and storage (...) of genetic variation in phenotypically normal populations. When buffering breaks down, thresholds governing the expression of previously silent variation are crossed. At these thresholds, phenotypic differences suddenly appear and are available for selection. Thus, buffering mechanisms modulate evolution and regulate a balance between evolutionary stasis and change. Recent work provides a glimpse of the molecular details governing some types of genetic buffering. BioEssays 22:1095–1105, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

The sports world has historically rejected the practice of tanking. I argue that this attitude is unwarranted. To do so, I introduce a concept called strategic suboptimal play (SSP), which is the practice of incurring the risk of a short-term competitive disadvantage to increase the chances of gaining a longer-term competitive advantage. Tanking is just an instance of SSP employed in higher-order games, i.e. games that are at least partially played by other games, like tournaments or seasons. Since SSP is (...) integral to every sport, there are currently no easy grounds for rejecting it outright. As such, the same is true of tanking. I will explore some possible reasons why tanking is wrongly thought objectionable, as well as some objections to and implications of my argument for competitive sports more broadly. (shrink)

The term fuzzy logic is used in this paper to describe an imprecise logical system, FL, in which the truth-values are fuzzy subsets of the unit interval with linguistic labels such as true, false, not true, very true, quite true, not very true and not very false, etc. The truth-value set, , of FL is assumed to be generated by a context-free grammar, with a semantic rule providing a means of computing the meaning of each linguistic truth-value in as a (...) fuzzy subset of [0, 1].Since is not closed under the operations of negation, conjunction, disjunction and implication, the result of an operation on truth-values in requires, in general, a linguistic approximation by a truth-value in . As a consequence, the truth tables and the rules of inference in fuzzy logic are (i) inexact and (ii) dependent on the meaning associated with the primary truth-value true as well as the modifiers very, quite, more or less, etc. (shrink)

Conceptual and methodological changes in ecology have the potential to alter significantly the way we view the world. A result of embracing a dynamic model has been to make ecological restoration projects a viable alternative, whereas under 'equilibrium ecology' restoration was considered destructive interference. The logic of sustainability strategies within the context of dynamic forces promises a greater compatibility with anthropogenic activity. Unhappily, environmental restoration turns out to be paradoxical under the current identification of wilderness with wildness where wildness is, (...) at least, a necessary condition for the possession of natural value. The solution to the paradox is to separate wilderness from wildness both conceptually and ontologically by enlarging the domain of wildness to include certain human activities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Poems Ancient and Contemporary HELAINE L. SMITH On the cover of Like: Poems by A. E. Stallings is a double photograph of a double image: two ancient carved heads, in profile and facing each other, of the pole horses of a quadriga, a four-horse chariot, dated about 570 BC, and currently in the collection of The Acropolis Museum. The marble horse in profile on the right side of the (...) cover, looking to the left, has a longer neck and face, and is undamaged except for a hairline crack at the neck. Its counterpart has a broader cheek, with light chipping above the nostril and an ear broken off. But they so mirror each other, they are so “like,” that at first glance one might suppose the photographs to be the right and left sides of the same horse. The bottom half of the cover of Like is an exact replica of the top, but the tinting is different, the heads in the top band cream-colored, in the arion 27.1 spring/summer 2019 Like: Poems by A. E. Stallings was published in 2018 by Farrar, Straus and Giroux, New York. Stallings’s earlier books of poetry include Archaic Smile (1999), Hapax (2006), Olives (2012), and a verse translation of Lucretius’ The Nature of Things (2007). bottom a delicate ochre or sand. There is, then, on the very cover of Like a promise of complex correspondence and subtle variation within the volume itself. Stallings’s title suggests poetry as the art of locating and articulating likeness or as the act of finding one thing in another. And in Stallings’s delicate, robust, witty, and humane use of the past, “like” also and most significantly means that they—the figures of ancient myth—and we are alike in our shared experience and shared humanity. Stallings sometimes presents classical and mythological references glancingly, and that is part of the delight—catching the joke in Hermes’ epithet, “lord of florists,”1 finding in “The Rosehead Nail” that the local blacksmith in Monteagle, Tennessee, “was a god / Before... the tasks / That had been craft were jobbed out to machine.” Likeness is, of course, the mode of Homeric simile, and in “Selvage” Stallings turns the simile of Odyssey 22.468–73, in which Homer compares the hanged maids to thrushes caught in a net, into a different but contextually relevant parallel: “they hang... From the warp like a dozen ancient loom weights,” a likeness that evolves from Stallings’s double entendre in line seven describing the maids as “spinsters of their own doom,” an allusion both to the task, properly theirs, of weaving and to their disclosure to their lovers of Penelope’s secret unravelling. Stallings can expand as well as adapt Homeric similes. At Iliad 2.87–2.90 Homer likens the Achaians’ assembly at Agamemnon’s command to arm and attack Troy to bees leaving the hive: Like the swarm of clustering bees that issue forever in fresh bursts from the hollow in the stone, and hang like bunched grapes as they hover beneath the flowers in springtime fluttering in swarms together this way and that way so the many nations of men from the ships and the shelters along the front of the deep sea beach marched in order by companies to the assembly2 178 poems ancient and contemporary Homer finds likeness in the orderly setting forth—of bees, of men—to do what is required. This, on the other hand, is what Stallings does: Colony Collapse Disorder (Iliad, 2.87–2.90) Just as a swarm pours from a hollow rock In one long beeline for the wild thyme, Alighting in clusters on this purple and that, But is stricken with a mass amnesia That disorients the compass of the sun, And they forget the steps to traditional dances, And each helicopters into a different dimness Taking their saddlebags of sweetness with them, And the hive goes dark, the queen is left to starve, And the drones humbug the whimper of the world, And the palace falls to ruins, broken into By vandals who would loot the golden stores Left in the brittle wax hexameters, Just so... And “so” her... (shrink)

Causation is at once familiar and mysterious. Neither common sense nor extensive philosophical debate has led us to anything like agreement on the correct analysis of the concept of causation, or an account of the metaphysical nature of the causal relation. Causation: A User's Guide cuts a clear path through this confusing but vital landscape. L. A. Paul and Ned Hall guide the reader through the most important philosophical treatments of causation, negotiating the terrain by taking a set of examples (...) as landmarks. They clarify the central themes of the debate about causation, and cover questions about causation involving omissions or absences, preemption and other species of redundant causation, and the possibility that causation is not transitive. Along the way, Paul and Hall examine several contemporary proposals for analyzing the nature of causation and assess their merits and overall methodological cogency.The book is designed to be of value both to trained specialists and those coming to the problem of causation for the first time. It provides the reader with a broad and sophisticated view of the metaphysics of the causal relation. (shrink)

The state of Alaska has a complex historical relationship with its wild wolf packs. The authors expand Connell's concept of frontier masculinity to interpret articles from the Anchorage Daily News as an alternative way to understand Alaska's shifting wolf policies. Originally, state policies were shaped by frontier masculinity and characterized by claims of sportsmen's rights to kill wolves. With the reinstitution of an aggressive wolf-eradication project, Alaska policy makers retooled frontier masculinity. This altered form of masculinity, retro frontier masculinity, is (...) constructed at the state level and deploys new strategic emphases: vilifying opponents as feminized sissies, casting wolf hunters as paternalist protectors, reifying the masculine family provider role, and framing the issue as fundamentally about competition. (shrink)

What is missing from most analyses of the gun crisis in America is an archetypal perspective. Archetypically, the Constitution is in the domain of the Bible in terms of it being the equivalent of a sacred text for Americans, making the Second Amendment a revered text for gun enthusiasts. It enshrines the insidious concept that people can rise up in armed resistance to an oppressive force, including the US government. The Minuteman is an archetypal mythic image in the American collective (...) unconscious for the Second Amendment. A gun confers wakan (Sioux), sacred power, upon its possessor, allowing them to wield in an instant the archetype of death. This moves conflicts into the archetypal categories of good‐vs‐evil and black‐and‐white, circumventing the system of laws upon which our country is based and averting the dialogue upon which a democracy depends. The cowboy is another mythic image, the lonely gun‐toting individual who fought off beasts and savages to tame the Wild West. The very concept of America as “a shining city on the hill” that inspired our Puritan (archetypal image) ancestors is from the Book of Revelation in the Bible. They were not averse to using guns to exterminate the “heathen savages” they encountered. The arsenal of guns in America amplifies growing tensions around income inequality, increasing corporate power and deteriorating racial relations and inner city conditions. (shrink)

Retinoblastoma is a highly malignant ocular tumor that has been known to be hereditary in some instances. New information from cytogenetic and molecular studies indicates that there is a retinoblastoma gene and that the mutant alleles are recessive. The wild‐type gene appears to be a suppressor of this neoplasia, and, when both alleles are lost, malignancy develops.

When your word processor or email program is running on your computer, this creates a "virtual machine” that manipulates windows, files, text, etc. What is this virtual machine, and what are the virtual objects it manipulates? Many standard arguments in the philosophy of mind have exact analogues for virtual machines and virtual objects, but we do not want to draw the wild metaphysical conclusions that have sometimes tempted philosophers in the philosophy of mind. A computer file is not made of (...) epiphenomenal ectoplasm. I argue instead that virtual objects are "supervenient objects". The stereotypical example of supervenient objects is the statue and the lump of clay. To this end I propose a theory of supervenient objects. Then I turn to persons and mental states. I argue that my mental states are virtual states of a cognitive virtual machine implemented on my body, and a person is a supervenient object supervening on his cognitive virtual machine. (shrink)

When your word processor or email program is running on your computer, this creates a “virtual machine” that manipulates windows, files, text, etc. What is this virtual machine, and what are the virtual objects it manipulates? Many standard arguments in the philosophy of mind have exact analogues for virtual machines and virtual objects, but we do not want to draw the wild metaphysical conclusions that have sometimes tempted philosophers in the philosophy of mind. A computer file is not made of (...) epiphenomenal ectoplasm. I argue instead that virtual objects are “supervenient objects.” The stereotypical example of supervenient objects is the statue and the lump of clay. To this end I propose a theory of supervenient objects. Then I turn to persons and mental states. I argue that my mental states are virtual states of a cognitive virtual machine implemented on my body, and a person is a supervenient object supervening on this cognitive virtual machine. (shrink)

Quine's early arguments in favor of "Ontological Relativity" depend on wild but interesting alternatives to standard ontology,most apparent when viewing his unusual idea of undetached object parts. In Quine's later philosophy, by contrast, he invokes trivial proxy functions and simple permutations to standard ontology, and in so doing paves the way for his claim of "Inscrutability of Reference". Nevertheless, Quine's more recent alternatives to standard ontology have thus far remained uninteresting for ontological questions, as his later arguments fail to offer (...) any real alternative to our standard identity relation. For this reason, I have chosen to return to Quine's original idea of "Ontological Relativity" and put it to the test. In my investigation, development and subsequent defense of Quine's original presentation, I attempt to show that it is in fact possible to read Quine's ontology of undetached object parts into a large sphere of our language. (shrink)

Best known for his two-year sojourn at Walden Pond in Massachusetts, Henry David Thoreau is often considered a recluse who emerged from solitude only occasionally to take a stand on the issues of his day. In _Thoreau’s Democratic Withdrawal_, Shannon L. Mariotti explores Thoreau’s nature writings to offer a new way of understanding the unique politics of the so-called hermit of Walden Pond. Drawing imaginatively from the twentieth-century German social theorist Theodor W. Adorno, she shows how withdrawal from the public (...) sphere can paradoxically be a valuable part of democratic politics. Separated by time, space, and context, Thoreau and Adorno share a common belief that critical inquiry is essential to democracy but threatened by modern society. While walking, huckleberrying, and picking wild apples, Thoreau tries to recover the capacities for independent perception and thought that are blunted by “Main Street,” conventional society, and the rapidly industrializing world that surrounded him. Adorno’s thoughts on particularity and the microscopic gaze he employs to work against the alienated experience of modernity help us better understand the value of Thoreau’s excursions into nature. Reading Thoreau with Adorno, we see how periodic withdrawals from public spaces are not necessarily apolitical or apathetic but can revitalize our capacity for the critical thought that truly defines democracy. In graceful, readable prose, Mariotti reintroduces us to a celebrated American thinker, offers new insights on Adorno, and highlights the striking common ground they share. Their provocative and challenging ideas, she shows, still hold lessons on how we can be responsible citizens in a society that often discourages original, critical analysis of public issues. (shrink)

I explore some of the ways that assumptions about the nature of substance shape metaphysical debates about the structure of Reality. Assumptions about the priority of substance play a role in an argument for monism, are embedded in certain pluralist metaphysical treatments of laws of nature, and are central to discussions of substantivalism and relationalism. I will then argue that we should reject such assumptions and collapse the categorical distinction between substance and property.

What if Wittgenstein and Popper were right after all? What is psychoanalysis is not “scientific,” not scientific by any contemporary definition—including Adolf Grünbaum’s—but what if it works all the same?1 What if psychoanalysis is all right in practice, but the theory isn’t scientific? Indeed, what if “science” is defined ideologically rather than philosophically? If we so redefine “science,” it is not to dismiss psychoanalysis but to understand its origin and impact, to follow the ideological dialectic between the history of psychiatry, (...) its developing as a medical “science,” and the evolving self-definition of psychoanalysis which parallels this history. We know that Freud divided psychoanalysis into three quite discrete areas—first, a theory, a “scientific structure”; second, a method of inquiry, a means of exploring and ordering information; and last, but certainly not least, a mode of treatment. Let us, for the moment, follow the actual course of history, at least the course of a history which can be described by sorting out the interrelationship between psychoanalysis and psychiatry, and assume that we can heuristically view the mode of treatment as relatively independent of the other two aspects of psychoanalysis. What if the very claims for a “scientific” basis for psychoanalytic treatment and by extension the role of the psychoanalyst as promulgated by Freud and his early followers were rooted in an ideologically charged historical interpretation of the positivistic nature of science and the definition of the social role of the scientist? This may seem an odd premise to begin an essay on the mutual influence of psychoanalysis and psychiatry, but it is not stranger than the actual historical practice. Psychoanalysis originated not in the psychiatric clinic but in the laboratories of neurology in Vienna and Paris.2 Its point of origin was not nineteenth-century psychiatry but rather nineteenth-century neurology. That origin points to a major difference between the traditional practice of nineteenth-century psychiatry and modern clinical psychiatry in our post-positivistic age. Psychiatry in nineteenth-century Europe, in Vienna as well as in Paris, was an adjunct to the world of the asylum. Indeed, the second great battle which nineteenth-century psychiatry waged was the creation of the “alienist” as a new medical specialty. The alienist was the medical doctor in administrative charge of the asylum, rather than a medical adjunct to the lay asylum director as had earlier, in the age of “moral treatment,” been the practice. Sander L. Gilman is professor of human studies in the departments of German literature and Near Eastern studies, Cornell University, and professor of psychiatry at the Cornell Medical College. He is the author of numerous books on intellectual and literary history. His most recent study is Jewish Self-Hatred . Forthcoming is his study Oscar Wilde’s London and the English edition of his Conversations with Nietzsche. His previous contribution to Critical Inquiry is “Black Bodies, White Bodies: Toward an Iconography of Female Sexuality in Late Nineteenth-Century Art, Medicine, and Literature”. (shrink)

Can human co-existence with wild animals can be mediated by an ethic of hospitality? Some Christian environmental and animal ethicists have outlined ways Christians can model a more expansive, imaginative, and informed hospitality toward non-human animals. This paper will explore philosophical and theological underpinnings for such a practice, to ask whether it can have any prescriptive “teeth” when the interests of humans and non-human, non-domestic animals collide in ways that humans perceive as costly. The paper will argue that a commitment (...) to interspecies hospitality can indeed function as a biocentric and biblical form of justice that adapts and extends community to our fellow creatures. (shrink)

Can human co-existence with wild animals can be mediated by an ethic of hospitality? Some Christian environmental and animal ethicists have outlined ways Christians can model a more expansive, imaginative, and informed hospitality toward non-human animals. This paper will explore philosophical and theological underpinnings for such a practice, to ask whether it can have any prescriptive “teeth” when the interests of humans and non-human, non-domestic animals collide in ways that humans perceive as costly. The paper will argue that a commitment (...) to interspecies hospitality can indeed function as a biocentric and biblical form of justice that adapts and extends community to our fellow creatures. (shrink)

It seems natural to choose whether to have a child by reflecting on what it would be like to actually have a child. I argue that this natural approach fails. If you choose to become a parent, and your choice is based on projections about what you think it would be like for you to have a child, your choice is not rational. If you choose to remain childless, and your choice is based upon projections about what you think it (...) would be like for you to have a child, your choice is not rational. This suggests we should reject our ordinary conception of how to make this life-changing decision, and raises general questions about how to rationally approach important life choices. (shrink)